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Plaquenil (hydroxychloroquine) is for treatment or prevention of malaria. This is a disease cause by parasites that enter the body through the bite of a mosquito.
Plaquenil is also use for symptoms treatment of rheumatoid arthritis and discoid or systemic lupus erythematosus.
Both chloroquine and hydroxychloroquine increase the endosomal pH, which inhibits fusion between SARS-CoV-2 and the host cell membrane.1 Chloroquine inhibits glycosylation of the cellular angiotensin-converting enzyme 2 (ACE2) receptor, which may interfere with the binding of SARS-CoV to the cell receptor.2 In vitro studies have suggested that both chloroquine and hydroxychloroquine may block the transport of SARS-CoV-2 from early endosomes to endolysosomes, possibly preventing the release of the viral genome.
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